{"id":337,"date":"2017-03-22T09:59:24","date_gmt":"2017-03-22T01:59:24","guid":{"rendered":"http:\/\/www.eedu.xyz\/?p=337"},"modified":"2017-03-22T09:59:24","modified_gmt":"2017-03-22T01:59:24","slug":"%e5%8a%9b%e5%ad%a6%e5%88%ba%e6%bf%80%e5%af%b9%e6%a4%8d%e4%bd%93-%e9%aa%a8%e7%95%8c%e9%9d%a2%e9%aa%a8%e7%b3%bb%e7%bb%86%e8%83%9emrna%e8%a1%a8%e8%be%be%e7%9a%84%e5%bd%b1%e5%93%8d","status":"publish","type":"post","link":"http:\/\/eedu.xyz\/?p=337","title":{"rendered":"\u529b\u5b66\u523a\u6fc0\u5bf9\u690d\u4f53-\u9aa8\u754c\u9762\u9aa8\u7cfb\u7ec6\u80demRNA\u8868\u8fbe\u7684\u5f71\u54cd"},"content":{"rendered":"<p><strong>\u529b\u5b66\u523a\u6fc0\u5bf9\u690d\u4f53<\/strong><strong>&#8211;<\/strong><strong>\u9aa8\u754c\u9762\u9aa8\u7cfb\u7ec6\u80de<\/strong><strong>mRNA<\/strong><strong>\u8868\u8fbe\u7684\u5f71\u54cd<\/strong><\/p>\n<p>Effects of the mRNA expression in implant-bone interface bone cells after mechanical stimulate<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\u6458\u8981<\/p>\n<p>\u5728\u5efa\u7acb\u529b\u5b66\u523a\u6fc0\u9aa8\u7cfb\u7ec6\u80de\u7684\u52a8\u7269\u5b9e\u9a8c\u6a21\u578b\u7684\u57fa\u7840\u4e0a\uff0c\u5229\u7528\u6fc0\u5149\u6355\u83b7\u663e\u5fae\u5206\u79bb\u6280\u672f\uff08LCM\uff09, 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[13]<\/sup>\u3002\u6210\u9aa8\u7ec6\u80de\u5728\u67d0\u4e9b\u529b\u5b66\u523a\u6fc0\u56e0\u7d20\u4f5c\u7528\u4e0b\u8868\u8fbe\u4e00\u4e9b\u56e0\u5b50\uff0c\u4ece\u800c\u5c06\u9aa8\u5438\u6536\u4fe1\u53f7\u4f20\u9012\u7ed9\u7834\u9aa8\u7ec6\u80de\u7684\u524d\u4f53\u7ec6\u80de\uff0c\u4f7f\u4e4b\u5206\u5316\u53d1\u80b2\u5e76\u6d3b\u5316\uff0c\u884c\u4f7f\u9aa8\u5438\u6536\u529f\u80fd\u3002\u9aa8\u4fdd\u62a4\u7d20\uff08OPG\uff09\u548c\u9aa8\u4fdd\u62a4\u7d20\u914d\u4f53\uff08OPGL\uff09\u7684\u53d1\u73b0\u8bc1\u5b9e\u4e86\u8fd9\u4e00\u5047\u8bf4\uff0c\u5e76\u63d0\u4f9b\u4e86\u5206\u5b50\u57fa\u7840<sup>[13-14]<\/sup>\u3002\u6709\u7814\u7a76\u8868\u660e<sup>[14-15]<\/sup>\uff1a\u4f5c\u4e3a\u7ec6\u80de\u8868\u9762\u91cd\u8981\u53d7\u4f53\u7684\u6574\u5408\u7d20\uff0c\u901a\u8fc7\u8bc6\u522b\u67d0\u4e9b\u80de\u5916\u57fa\u8d28\u86cb\u767d\uff0c\u4ecb\u5bfc\u7ec6\u80de\u4e0e\u7ec6\u80de\u3001\u7ec6\u80de\u4e0e\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u7c98\u9644\u53cd\u5e94\u5e76\u63a5\u53d7\u3001\u8f6c\u5bfc\u7ea7\u8054\u4fe1\u53f7\uff0c\u5e76\u6709\u53ef\u80fd\u662f\u529b\u5b66\u4fe1\u53f7\u4f20\u9012\u7684\u901a\u9053\u3002<\/p>\n<p>\u4ece\u4ee5\u4e0a\u7814\u7a76\u4e2d\u53ef\u4ee5\u770b\u51fa\uff1a\uff081\uff09\u529b\u5b66\u523a\u6fc0\u5bfc\u81f4OB\u3001OC\u57fa\u56e0\u6539\u53d8\u7684\u8fc7\u7a0b\u6d89\u53ca\u4f17\u591a\u57fa\u56e0\u7684\u53d8\u5316\uff0c\u4f46\u9488\u5bf9\u4e2a\u522b\u57fa\u56e0\u7684\u7814\u7a76\u663e\u5f97\u8f83\u4e3a\u51cc\u4e71\uff0c\u57fa\u56e0\u4e4b\u95f4\u7684\u76f8\u4e92\u5f71\u54cd\u4e5f\u4e0d\u6e05\u695a\uff0c\u4e0d\u80fd\u7cbe\u786e\u5730\u9610\u660e\u5404\u57fa\u56e0\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\u3002\uff082\uff09\u591a\u6761\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def\u4e4b\u95f4\u5b58\u5728\u7740\u5bc6\u5207\u7684\u8026\u8054\u5173\u7cfb\uff0c\u4e0d\u540c\u7684\u529b\u5b66\u4fe1\u53f7\u53ef\u80fd\u901a\u8fc7\u8fd9\u4e9b\u5185\u5728\u76f8\u8fde\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u4ee5\u4e0d\u540c\u7684\u65b9\u5f0f\u5f71\u54cd\u9aa8\u7cfb\u7ec6\u80de\u7684\u53cd\u5e94\u3002\u8fd9\u4e9b\u4e0d\u540c\u4fe1\u53f7\u901a\u9053\u662f\u5982\u4f55\u4ecb\u5bfc\u529b\u5b66\u523a\u6fc0\uff0c\u800c\u5bfc\u81f4OB\u3001OC\u57fa\u56e0\u8868\u8fbe\u7684\u65f6\u7a7a\u53d8\u5316\uff1f\u662f\u5426\u5b58\u5728\u67d0\u4e9b\u5c1a\u4e0d\u4e3a\u4eba\u6240\u77e5\u7684\u4fe1\u53f7\u8f6c\u5bfc\u5206\u5b50\uff1f\u4fe1\u53f7\u901a\u8def\u4e4b\u95f4\u53c8\u662f\u5982\u4f55\u8026\u8054\u7684\uff1f\u8fd9\u65b9\u9762\u7684\u8ba4\u8bc6\u5c1a\u4e0d\u660e\u786e\uff0c\u53ea\u80fd\u4ece\u57fa\u56e0\u8868\u8fbe\u7684\u53d8\u5316\u6765\u627e\u5bfb\u65b9\u5411\u3002\uff083\uff09\u7531\u4e8e\u5404\u5b66\u8005\u591a\u91c7\u7528\u4f53\u5916\u5b9e\u9a8c\uff0c\u5b9e\u9a8c\u6761\u4ef6\u4e0d\u5c3d\u76f8\u540c\uff0c\u5bfc\u81f4\u5b9e\u9a8c\u7ed3\u679c\u7684\u53ef\u6bd4\u6027\u8f83\u5dee\uff0c\u6709\u5173\u4f53\u5185\u5b9e\u9a8c\u7684\u62a5\u9053\uff0c\u7279\u522b\u662f\u529b\u5b66\u523a\u6fc0\u5bf9\u4eba\u5de5\u79cd\u690d\u4f53-\u9aa8\u754c\u9762\u9aa8\u7cfb\u7ec6\u80de\u57fa\u56e0\u8868\u8fbe\u5f71\u54cd\u7684\u62a5\u9053\u4e5f\u6781\u4e3a\u7f55\u89c1\u3002\u56e0\u6b64\uff0c\u6709\u5fc5\u8981\u540c\u671f\u4ece\u4f53\u5185\u5916\u89c2\u5bdfOB\u3001OC\u53d7\u529b\u540e\u6574\u4e2a\u57fa\u56e0\u8868\u8fbe\u7684\u65f6\u5e8f\u53d8\u5316\uff0c\u63a2\u8ba8\u5404\u76f8\u5173\u57fa\u56e0\u5728\u9aa8\u5f62\u6210\u548c\u9aa8\u5438\u6536\u8fc7\u7a0b\u4e2d\u7684\u786e\u5207\u4f5c\u7528\uff0c\u5e76\u63a2\u8ba8\u5176\u4e34\u5e8a\u5e94\u7528\u524d\u666f\u548c\u610f\u4e49\u3002<\/p>\n<p>Vaes<sup>[16]<\/sup>\u7b49\u4eba\u66fe\u5c1d\u8bd5\u5e94\u7528\u57fa\u56e0\u82af\u7247\u7684\u65b9\u6cd5\uff0c\u627e\u5bfb\u9aa8\u5f62\u6210\u86cb\u767d-2\u8bf1\u5bfc\u6210\u9aa8\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\u7684\u6807\u8bb0\u57fa\u56e0\uff0c\u4e3a\u63a2\u5bfb\u529b\u5b66\u4fe1\u53f7\u5bf9\u9aa8\u7cfb\u7ec6\u80de\u57fa\u56e0\u8868\u8fbe\u7684\u5f71\u54cd\u63d0\u4f9b\u4e86\u4e00\u4e2a\u597d\u7684\u601d\u8def\u3002\u57fa\u56e0\u82af\u7247\u6280\u672f\u662f\u4e00\u9879\u65b0\u5174\u7684\u80fd\u68c0\u6d4b\u5168\u8303\u56f4mRNA\u8868\u8fbe\u6c34\u5e73\u53d8\u5316\u7684\u6280\u672f\uff0c\u5177\u6709\u9ad8\u901a\u91cf\u3001\u5e76\u884c\u5316\u7684\u7279\u70b9\uff0c\u53ef\u4e3a\u7814\u7a76\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u53ca\u5176\u673a\u7406\uff0c\u63ed\u793a\u4e0d\u540c\u5c42\u6b21\u591a\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528\u7684\u751f\u7406\u3001\u75c5\u7406\u73b0\u8c61\u63d0\u4f9b\u6709\u6548\u624b\u6bb5<sup>[17,18]<\/sup>\u3002\u7136\u800c\uff0c\u9aa8\u7ec4\u7ec7\u662f\u4e0d\u540c\u7ec6\u80de\u7fa4\u4f53\u76f8\u4e92\u4f5c\u7528\u7684\u4e09\u7ef4\u7a7a\u95f4\u7ed3\u6784\uff0c\u901a\u8fc7\u78e8\u788e\u6d3b\u7ec4\u7ec7\u6240\u63d0\u53d6\u7684DNA\u3001RNA\u4e0d\u80fd\u4ee3\u8868\u7279\u5b9a\u751f\u7406\u6216\u75c5\u7406\u8fc7\u7a0b\u4e2d\u5355\u4e00\u540c\u7c7b\u7ec6\u80de\u7684\u4fe1\u606f\u3002\u6fc0\u5149\u6355\u83b7\u663e\u5fae\u5207\u5272\u6280\u672f<sup>[19]<\/sup>\uff08Laser Capture Microdissection \uff0cLCM\uff09\u5219\u662f\u89e3\u51b3\u7ec6\u80de\u5f02\u8d28\u6027\u95ee\u9898\u7684\u9769\u547d\u6027\u6280\u672f\uff0c\u662f\u5728\u663e\u5fae\u955c\u4e0b\u4ece\u7ec4\u7ec7\u5207\u7247\u4e2d\u5206\u79bb\u3001\u7eaf\u5316\u5355\u4e00\u7c7b\u578b\u7ec6\u80de\u7fa4\u6216\u5355\u4e2a\u7ec6\u80de\u7684\u6280\u672f\u3002\u4eceLCM\u6355\u83b7\u7684\u540c\u8d28\u7ec6\u80de\u4e2d\u63d0\u53d6mRNA\u53ef\u6784\u5efacDNA\u6587\u5e93\uff0c\u8fdb\u884ccDNA\u5fae\u5217\u9635\u5206\u6790<sup>[20]<\/sup>\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u76f8\u4fe1LCM\u6280\u672f\u4e0e\u57fa\u56e0\u82af\u7247\u7684\u6709\u6548\u7ed3\u5408\uff0c\u5c06\u80fd\u591f\u6e05\u6663\u5730\u52fe\u753b\u51fa\u529b\u5b66\u523a\u6fc0\u540e\u4eba\u5de5\u79cd\u690d\u4f53-\u9aa8\u754c\u9762OB\u3001OC\u5728\u751f\u7406\u3001\u75c5\u7406\u8fc7\u7a0b\u4e2d\u7684\u57fa\u56e0\u8868\u8fbe\u7684\u6539\u53d8\u3002<\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u9aa8\u4f5c\u4e3a\u4e00\u4e2a\u81ea\u9002\u5e94\u7684\u751f\u7269\u7cfb\u7edf\u662f\u901a\u8fc7\u591a\u5c42\u9762\u3001\u591a\u56e0\u7d20\u7684\u7f51\u7edc\u8c03\u63a7\u6765\u5b8c\u6210\u5e94\u529b\u4f5c\u7528\u4e0b\u7684\u9aa8\u6539\u5efa\uff0c\u663e\u7136\u4ee5\u5f80\u53ea\u9488\u5bf9\u5176\u4e2d\u67d0\u4e00\u5c42\u9762\u3001\u82e5\u5e72\u56e0\u7d20\u7684\u5355\u4e00\u89c6\u89d2\u7684\u7814\u7a76\uff0c\u96be\u4ee5\u7cfb\u7edf\u900f\u5f7b\u5730\u9610\u8ff0\u5e94\u529b\u4f5c\u7528\u4e0b\u9aa8\u5f62\u6210\u548c\u9aa8\u5438\u6536\u7684\u57fa\u56e0\u8c03\u63a7\u673a\u5236\u3002\u56e0\u6b64\u6709\u5fc5\u8981\u4ece\u6574\u4e2a\u57fa\u56e0\u7ec4\u7684\u6c34\u5e73\u63a2\u8ba8\u5e94\u529b\u4f5c\u7528\u4e0b\u9aa8\u7cfb\u7ec6\u80de\u4e0a\u5343\u4e2a\u57fa\u56e0\u7684\u52a8\u6001\u8868\u8fbe\uff0c\u65e2\u8981\u4ece\u5206\u5b50\u6c34\u5e73\u6765\u7814\u7a76\u5176\u673a\u7406\uff0c\u4e5f\u8981\u4ece\u7cfb\u7edf\u5c42\u9762\u52a8\u6001\u7814\u7a76\u9aa8\u7cfb\u7ec6\u80de\u57fa\u56e0\u7684\u65f6\u5e8f\u53d8\u5316\uff0c\u628a\u5206\u6790\u548c\u7efc\u5408\u7edf\u4e00\u8d77\u6765\uff0c\u540c\u65f6\u4e5f\u53ef\u4ee5\u5bf9\u76ee\u524d\u4f17\u591a\u5355\u57fa\u56e0\u6c34\u5e73\u7684\u7814\u7a76\u8fdb\u884c\u5206\u6790\u3001\u8bc4\u4ef7\u548c\u6bd4\u8f83\uff0c\u4ece\u800c\u660e\u786e\u4e0d\u540c\u529b\u5b66\u523a\u6fc0\u5bfc\u81f4\u9aa8\u5f62\u6210\u548c\u9aa8\u5438\u6536\u7684\u57fa\u56e0\u8c03\u63a7\u7684\u5f02\u540c\uff0c\u8bd5\u56fe\u53d1\u73b0\u65b0\u7684\u91cd\u8981\u7684\u8c03\u63a7\u57fa\u56e0\uff0c\u7b5b\u9009\u51fa\u80fd\u7279\u5f02\u6027\u8868\u660e\u9aa8\u5f62\u6210\u548c\u9aa8\u5438\u6536\u7684\u201c\u6807\u8bb0\u201d\u57fa\u56e0\uff0c\u4e0d\u4ec5\u4e3a\u9aa8\u751f\u7269\u529b\u5b66\u53ca\u9aa8\u7ec4\u7ec7\u5de5\u7a0b\u5b66\u63d0\u4f9b\u7406\u8bba\u4f9d\u636e\uff0c\u800c\u4e14\u5bf9\u8d1f\u8377\u72b6\u6001\u4e0b\u9aa8\u7ec4\u7ec7\u4e0e\u4eba\u5de5\u6750\u6599\u754c\u9762\u9aa8\u6539\u5efa\u673a\u5236\u7684\u8ba4\u8bc6\u3001\u4e34\u5e8a\u8bca\u65ad\u548c\u9632\u6cbb\u7b49\u4e5f\u6709\u91cd\u8981\u7684\u610f\u4e49\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n<p>1\u3001Lee TC, Staines A, Taylor D. Bone adaptation to load: microdamage as a stimulus for bone<\/p>\n<p>remodelling. J Anat. 2002 Dec;201(6):437-46.<\/p>\n<p>2\u3001Femor B,Cundle R, Evans M,et al.Primary human osteoblast proliferation and prostagland in E2 release in response to mechanical strain in vitro. Bone ,1998;22(6:)637.<\/p>\n<p>&nbsp;<\/p>\n<p>4\u3001Peake MA, El Haj AJ.Preliminary characterisation of mechanoresponsive regions of the c-fos promoter in bone cells.FEBS Lett. 2003 Feb 27;537(1-3):117-20.<\/p>\n<p>5\u3001Kletsas,Dimitris,Basdra,et al. Effect of proteinkinase Inhibitor on the stretch-elicited c-fos and c-jun up-regulation In human PDL osteoblast-like cells [J].Cell Physiol,2002,190(3):313\u2014321.<\/p>\n<p>6\u3001Ikegame M,Ishibashi O,YOSHIZAWA T,et al.Tensile stress Induces bone morphogenetic protein 4 in preosteoblastic and fibroblastic cells,which later differentiate into osteoblasts leading to osteogenesis in the mouse calvariae in organ culrure [J]Bone Miner Res,2001,16(1):24-32.<\/p>\n<p>7\u3001Pavlin D, Zadro R, Gluhak-Heinrich J. Temporal pattern of stimulation of osteoblast-associated genes during mechanically-induced osteogenesis in vivo: early responses of osteocalcin and type I collagen. Connect Tissue Res. 2001 Oct;42(2):135-48.<\/p>\n<p>8\u3001 Cillo JE,Gassner R,Koepsel RR, et al. 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Science 1999 August 13; 285: 1028-1033.<\/p>\n<p>15\u3001Li L, Chen M, Deng L, Mao Y, et al.The effect of mechanical stimulation on the expression of alpha 2, beta 1, beta 3 integrins and the proliferation, synthetic function in ratosteoblasts.Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2003 Jun;20(2):187-92.<\/p>\n<p>16\u3001Vaes BL, Dechering KJ, Feijen A, et al.Comprehensive microarray analysis of bone morphogenetic protein 2-induced osteoblast differentiation resulting in the identification of novel markers for bone development.J Bone Miner Res. 2002 Dec;17(12):2106-18.<\/p>\n<p>17\u3001Schena M.Shalon D. Davis R W. Brown P O.Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray. Science,1995,270(20):467-470.<\/p>\n<p>18\u3001Qackenbush J. Genomics Microarrays&#8211;guilt by association\u00a0\u00a0 science,2003, 302(5643):249-55.<\/p>\n<p>19\u3001Yim SH, Ward JM, Dragan Y, et al.Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene expression profiles.Toxicol Pathol. 2003 May-Jun;31(3):295-303.<\/p>\n<p>20\u3001Ying SY, Lin SL.Gene expression in precursor cells of prostate cancer associated with activin by combination of subtractive hybridization and microarray technologies.Biochem Biophys Res Commun. 2004 Jan 2;313(1):104-9.<\/p>\n<div class='img-xxx-con'><iframe data-aa='2305450' src='\/\/ad.a-ads.com\/2305450?size=468x60' style='width:468px; height:60px; border:0px; padding:0; overflow:hidden; background-color: transparent;'><\/iframe><\/div>","protected":false},"excerpt":{"rendered":"<p>\u529b\u5b66\u523a\u6fc0\u5bf9\u690d\u4f53&#8211;\u9aa8\u754c\u9762\u9aa8\u7cfb\u7ec6\u80demRNA\u8868\u8fbe\u7684\u5f71\u54cd Effects of the mRNA expression in implant-bone interface bo <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"gutentor_comment":0,"_links":{"self":[{"href":"http:\/\/eedu.xyz\/index.php?rest_route=\/wp\/v2\/posts\/337"}],"collection":[{"href":"http:\/\/eedu.xyz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/eedu.xyz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/eedu.xyz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/eedu.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=337"}],"version-history":[{"count":0,"href":"http:\/\/eedu.xyz\/index.php?rest_route=\/wp\/v2\/posts\/337\/revisions"}],"wp:attachment":[{"href":"http:\/\/eedu.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=337"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/eedu.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=337"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/eedu.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}